The Studies on Testosterone Replacement Therapy Testosterone replacement studies that recently made news and received ample attention were published in PLOS One in January 2014, JAMA in November 2013, and the NEJM in July 2010. The studies reported an increase in cardiac risks and higher rate of heart attacks in patients undergoing testosterone replacement therapy. The PLOS One study is the most recent of the studies mentioned above and gained national coverage in the New York Times. After reading these recent studies, one might reconsider undergoing testosterone replacement therapy. Then …