Patient Stories, Reviews, & Case Studies

Hear from Real People about Their Successes in Longevity Medicine

Losing Weight, Gaining Energy
“After years of struggling I finally feel like myself again. I am losing weight and have my energy back. Thank you for guiding me through this process and reassuring me all the way. You have been easy to communicate with, kind and responsive – can’t thank you enough!”

-Cathryn B. C., Facebook Review

Great Results from Working with Dr. Brandt
“Started with Dr. Brandt 1 yr. ago. Results have been fantastic. My athletic stamina has improved dramatically, and I’ve lost approx. 15 lbs. and improved lean muscle mass. I would absolutely recommend working with Dr. Brandt.”

-Lenny C., Vitals.com Review

Crazy Hormones Under Control
“Dr. Brandt has not only helped me get my crazy hormones under control, but he recently did a stem cell procedure on my back. As a result, I am able to function virtually pain free for the first time in months! Everyone at ThriveMD Vail also made me feel very comfortable and handled every detail of my appointments with professionalism and promptness. Thank you, Dr. Brandt, Debi, Alison, and Sue!”

-Jenn from Boulder, Colorado; Google Review

Very Good – The Best
“Hormone Replacement Works and adds life to your years, and years to your life.”

-Vail Valley Patient, Vitals.com Review

Thrilled with the Progress
“I am so happy to have found Thrive this past summer. After being told by 3 Dr’s that I need a knee replacement I was feeling very discouraged. 2 1/2 years ago I had a very bad skiing accident and destroyed my tibial plateau. After surgery and physical therapy I was nowhere near where I wanted to be functioning physically. I couldn’t hike, ski, or basically do anything active without constant pain. I went to Thrive and got my hormones balanced, got my energy level back up to where I like it to be and had several stem cell treatments on my knee. It was not an instant fix, but over the past 6 months it has continually started to feel better. I just skied 3 hard days in a row in Beaver Creek, with no swelling and very little pain! I am back to functioning at about 80% of my capacity. I’m thrilled with the progress and hope to continue to improve as I continue to be active this winter. I am so happy not to have a knee replacement and to be able to keep my own knee. Thank you Dr. Brandt.”

-Karen from Littleton, Colorado; Google Review

Walk Through Walls, All Day Long
“Dr. Brandt’s medicine is life giving. It is not a band-aid and not a temporary fix. He manages my bio-identical hormone replacement long distance, and the result is life changing. I once stopped taking the supplements for several months, because I was curious, and I quicky fell back into difficult mornings and unbearable fatigue in late afternoons. When I went back to Dr Brandt’s carefully balanced supplementation plan, I again felt that I could walk through walls, all day long. I can only imagine how much better my academic and work performance might have been, had I had this option 10, 20, and 30 years ago.”

-Billie from Vail Valley, Colorado; Vitals.com Review

No More Osteopenia
“Now that I’ve reached my very late 60’s I realize how lucky I am. Dr. Brandt has been treating me with HRT (Hormone Replacement Therapy) for 1 1/2 years and the results have been tremendous. I am now stronger more vibrant than ever. This season I skied 53 days without any incidents….just pure pleasure and always with a smile on my face. Life is certainly getting better with HRT. Dr. Brandt and his staff have been great. One of the most amazing things has been the result of my last bone density test. I went from osteopenia to NORMAL. Wow! Thanks to Dr. Brandt and everyone at Thrive MD…..You are the Best!!!!!!”

-Susan from Vail, Colorado; Vitals.com Review

Feeling Better than Ever
“Dr. Brandt is very knowledgeable in treating declining hormone levels. I feel better than ever. I thought feeling sluggish was part of aging. I was wrong. Now that I’m hormonally optimized, I have more energy and globally feel great. Dr. Brandt is warm and personable and cares about his patients.”

-Vitals.com Review

Why Is Just OK… OK?
“Did I need Hormone Replacement Therapy? Not me. Everything is OK. Dr. Brandt and his wonderful staff asked, ‘Why is OK, OK? You can be better or great.’ Retired in December as I approached the 70 mark and wanted to see how I could ski this season. With HRT I skied 57 days at Vail with almost 750,000 feet of vertical. Stamina was great. Never tired or winded. Skied everything, including Highline from top to bottom. Thank you Dr. Brandt and team!!!!!”

-Larry from Vail, Colorado; Vitals.com Review

Feeling Fantastic
“Feeling fantastic! I no longer feel my afternoon exhaustion and my energy and libido are significantly improved. Thanks to Dr. Brandt, I am hormonally optimized.”

-Vitals.com Review

Looking Better Than Years Ago
“I have worked with Scott Brandt, MD in various capacities since 1999. Since he now stays up in the mountains, I have entrusted my ‘’aging’ care to him as well as to some of my friends. Clinically trained friends and acquaintances to him for regenerative minimally invasive PRP and stem cell (with great success). Now as a patient of his in bioidentical hormones, I give him the highest rating possible. Everyone tells me I look better than I did years ago. Thank you, Dr. Brandt!”

-Joni from North Tonawanda, NY; LinkedIn Review

Lower Cholesterol and Enjoying the Outdoors
“I came to Dr Brandt after fighting an escalating cholesterol problem compounded by a lack of testosterone in my system. After some analysis and looking into my current conditions Dr Brandt created a plan for my specific situation and it was put into motion. Today after my 6 week checkup I was talking with Dr Brandt about not realizing how lousy I originally felt with my very low testosterone situation and worrying about my cholesterol which seemed to keep rising even though I was adjusting my diet and exercise. Today I can say that my cholesterol went from 238 to 183 in 6 weeks and my testosterone levels continue to recover which has me feeling good again. The effect of his treatments has left me feeling solid and encouraged about my future and ability to keep enjoying the things I love to do outside! If you feel like you got run over by a bus every day, take some action. There is help available.”

-John from Vail Valley, Colorado; Email Testimonial

Having Fun Again
“Just wanted to drop you a quick note and say thank you! With the program we are on my energy levels, attitude and consistent emotional state of years past is returning. And, the difference has been noticed at work resulting in great reviews and a promotion. At my age that is really surprising and unexpected! I know it is a combination of your program, physical fitness and my work ethic but it was not coming together before. In fact it felt like it was falling apart at times. I am having fun again at work and after work! So thank you for the help.”

-Charles from Little Rock, Arkansas; Email Testimonial

64 & Feeling 40 Again
“My first visit with Dr. Scott Brandt at ThriveMD was in March, 2013 and today, July 24, 2013, I feel like a new woman. I am 64 years old and I feel 40 again! Not only do I have energy, my skin looks fabulous, my ‘menopot’ is gone, I sleep like a baby, I feel sensuous, alive, sexy and my brain is working again. In addition, my total cholesterol went down over 70 points!! My regular MD had been trying to put my on medication for that for several years but I kept arguing that something was wrong, I had never had high cholesterol….now with balanced bioidentical hormones, my numbers went down on their own because that is my normal state. I am not the average 64 year old any more. I am an optimal feel-like-40, 64 year young woman!!! Dr. Brandt is a caring, thoughtful, brilliant doctor, and for me, a Miracle Worker!! I am sending all my friends to him because we have been forgotten by the regular medical professionals and it’s time to take back our lives!!”

Lynn from Vail Valley, Colorado; Email Testimonial

Cholesterol, Statins & Homeopathics
“I think this is pretty amazing. Enclosed are copies of most recent blood tests going back to 7/31/10. My cholesterol kept creeping up even though I have eaten healthy and exercised most of my life. Although some of the drugs I take for RA, mainly Humira, can make these figures higher, I was still concerned about these numbers. Dr. McSteven prescribed statins, which I took for about 3 months and hated. Not only did my cholesterol not go down significantly, but my memory and ability to recall anything was totally diminished. Against Dr. McSteven’s advise, I quite taking statins.

This past summer I started on hormone therapy at ThriveMD and the homeopathic Cardiac Essentials from Vail Valley Pharmacy. Last week I had blood work done for a pre-op exam. The results are really astonishing. Everything was well within normal range –first time in years! I think it’s good to have first hand positive results (right there in blood and ink!) from one of your patients. Thank you all so much!”

-Marjorie from Vail Valley, Colorado; Email Testimonial

Grateful
“Before I could not walk at all for long periods of time and was in constant pain, having to take an assortment of medications. In less than 5 months I can walk and swelling is down to minimal. I can ride a bike again and my health is returning. Dr. Brandt was also able to help me with my thyroid and hormone problems.

Words cannot express my gratefulness to you and your staff.”

-Don from Vail Valley, Colorado; Email Testimonial

BHRT for Women
“Dear Dr. Brandt, After all your help analyzing my health status, I want you to know that I FEEL JUST GREAT!!!!! Thank you for your expertise in enabling me to find the right hormones I need to feel as good as I do now.”

-Jane, Email Testimonial

Effectively Treated Bad Spinal Discs
“Dr Brandt and his team at ThriveMD clinic are caring and professional. They have effectively treated bad spinal discs on both myself and well as my wife. If you can avoid risky surgeries with non invasive Stem cell treatment, why not.”

-Google Review

Drastically Improved my Quality of Life
“Dr. Brandt and the whole team at ThriveMD are amazing! They treat you like family and are warm and welcoming. The treatments I have had at their clinic have drastically improved my quality of life and I recommend them to anyone seeking pain relief.“

-Google Review

Playing More Golf at 70 Than Any Other Time in Life
“I just felt I needed to tell you a little bit about my status. I was a patient in October and November 2018 and came to Lone Tree from Iceland to receive some stem cell therapy in my lower back. I didn’t feel any benefits at all for a very long time and was starting to think that the shots had not worked. After about a year from the shots, in October 2019 I suddenly felt it. Everything was quiet. No pain… Nothing… I have been absolutely pain-free since then and I am having a ball. The quality of life today compared to the decades of pain is staggering. I’m 70 years old now and last year I played more golf than at any time in my 40-year golf life. Club champion and in the Icelandic senior golf team. And it didn’t hurt…To think that I was at my wit’s end because of the endless pain in my back and the future was looking pretty bleak. So I started googling and found you. This is a remarkable turnaround and I cannot thank you enough. Life is good…”

-Direct Message from Patient

Thrilled with the Stem Cell Injections in My Neck
“I’m thrilled with the stem cell injections from Dr. Brandt in my neck. After living with severe chronic pain for almost six years, I sent my MRI to Dr. Brandt. He thought he could help me and I traveled from Iowa to Denver for the stem cells. While there was significant pain after the first procedure, it was more than worth it. Six months out, I have little pain and much better mobility. I would recommend Dr. Brandt to all those living with chronic pain.”

-Direct Message from Patient

Touching My Toes Again
“I had injections on my L5/S1 discs 3 months ago and started PT a week after the procedure. Though I still have work do to in PT to strengthen my core and glute muscles to support my spine, I have noticed less ‘creakiness’ and stiffness in my spine since the procedure. I can bend over and touch my toes for the first time in almost two years! Doctor Brandt and his team are incredibly kind and helpful. The procedure was incredibly smooth and I was surprised how quickly I felt like myself again. Doctor Brandt expects that I will see even more improvement over the next 3 months – I can’t wait for even more mobility and less pain!”

-Direct Message from Patient

Avoided Disc Surgery, Now 100% Pain-Free
“Dr. Brandt and the entire ThriveMD Team are delivering an innovative protocol for treating patients who have been suffering in pain. From the front office to Dr. Brandt, total compassion and understanding of the issues patients are going through that would bring them you to ThriveMD offices. My personal experience prior to treatment with Dr. Brandt has been one of being in excoriating pain for a long period of time from multiple herniated discs. After an exhaustive search for a remedy, including visits to Harvard, University of Colorado and Stanford, physicians all recommended surgery. I was convinced this was not the answer. One visit for the procedure and a follow-up, after a year, 100% pain-free. The science is compelling, as are the final results speak for themselves, drug and pain-free. This is my first recommendation for any medical procedure, ThriveMD is doing amazing work and I suggest if you suffer seek them out it is worth it, you get your life back.”

-Marc from Denver, Facebook Review

On a Golf Trip in Ireland, Pain Free
“August 2017 I hurt my lower back (L5/S1 and facet joints) to the point where I could not swing a golf club without excruciating pain. I often times went to my knees after sitting too long and standing up and thought I would never play golf again. Fast forward to March 2018 when Dr. Brandt injected my L5/S1 and facets on both sides. I had already committed to a golf trip to Ireland at the end of June, so I needed help after trying yoga, chiropractic, dry needling, pilates, stretching, Egoscue, you name it nothing worked. For the first two months I thought the procedure was a failure. I had more pain sometimes and really no relief and again thought I would never play golf again. In late May I decided to go for it and went to hit golf balls. I was tentative and had some pain, but nothing like I expected. I then continued to play and made it to Ireland, and through Ireland, pain free. Today I have no reservations about any activity and I play as much golf as ever. I believe this procedure provided me with everything it was advertised to be and I couldn’t be happier. I encourage anyone to go see Dr. Brandt and talk to him. Understand that it is not an overnight miracle, but takes time. I was very discouraged for the first two months. Maybe mind over matter played into it thereafter, but whatever it was ,it worked.”

-Scott from Greater Denver Area; Google Review

Continuing to Have Significant Improvement
“I had a procedure on my low back 4 years ago and I continue to have significant improvement. I’m amazed!”

-Direct Message from Patient

Four Years after the Stem Cell Procedure & Still Feels Great
“It’s been 4 years since my stem cell procedure on my low back and my day to day activities are still pain free. Every once in a while (not often) I have a flare up but with much less intensity and shorter duration than the 20 years of pain I had leading up to my stem cell procedure.”

-Direct Message from Patient

Grateful for the Genuine Care
“It’s only been a short while, but I want to express how grateful I am to have found a medical office like Thrive. Far beyond the actual procedure, the manner in which you treat patients and our concerns and sometimes silly questions and scary moments, I’ve gone to many doctors and never experienced this level of genuine care. So thank you. Thank you a ton.”

-Clare from Iowa; Patient Follow-Up

Looking Forward to an Active Lifestyle Again
“I had back pain from 5 degenerating discs. I had 3 consults from different medical institutions and all had said that I would need fusion of 5 discs and 2 rods inserted into my back. I sent my MRI to Dr. Brandt and after review he said he thought he could help. I found Dr. Brandt’s office very helpful and informative. I am currently one out from my 2nd appointment and doing incredibly well. The pain and discomfort are gone! I am currently engaged in exercise to strengthen my lower back and abdominal muscles. I am looking forward to an active lifestyle again. I selected Thrive MD due to Dr. Brandt’s experience in the stem field. The are many offices and medical centers that are beginning to get involved in the stem cell arena. I wanted a Doctor that has been doing this for a while and getting great results. Dr. Brandt has a kind and caring attitude, as well as his staff. I would highly recommend Thrive MD and already have sent many patients to him.”

-Dr. Brian Bouck; Google Review

Back Pain Improved & Returned to Activities Pain Free
“I’ve had two successful stem cell procedures performed by Dr. Brandt (knee and back). I’ve resumed playing golf, riding my bike, and skiing, relatively pain free. I would highly recommend Dr. Brandt.”

-Frank, Patient Review

Back Pain Significantly Better
“So far my back pain is significantly better and I am looking forward to my next procedure.”

-Elizabeth from Boulder, CO; Patient Follow-Up One Month Post Procedure

Avoided Back Surgery
“I don’t often leave reviews; however, I feel compelled to rate Dr. Brandt with as many stars as possible. I suffered from chronic back pain for over 8 years. I consulted with 3 different orthopedic/ neuro surgeons, and the general consensus was to operate, or continue to live with the pain. After many hours of researching my options, I decided to try a stem cell procedure with Dr. Brandt. I am now 5 months post that procedure, and I can’t be happier. Most days I’m 95% pain free, and I have resumed all of my physical activities, including running, biking, skiing golfing and hiking. In summary, I would highly recommend Dr. Brandt, without any reservation.”

-Frank, Google Review

No More Need for Pain Medication
“Until my consultation with Scott Brandt, MD., I was faced with two not very desirable options for my chronic lower back pain caused from a bulging disc and spondylolisthesis: continue RF neurotomy procedures every 6 months to burn nerves in my back for pain relief or spinal fusion surgery. The first was a band-aid, the second not an option I wanted. Dr. Brandt’s diagnostic sophistication, attention to detail and patient-focus became very apparent during our phone consultations reviewing all of my x-rays and two MRI results. He gave me more information in 30 minutes than I’d had from three specialists in four years of treatment. I went through stem cell therapy treatment with him and since have not needed pain medication, am able to get out of bed in the morning without limping, and can perform my job without wearing braces or heat patches. My posture has improved remarkably because I’m not hunching in pain. I actually gave myself a pedicure two weeks ago – which was a crippling no-go activity previously. Four years ago I woke up 10-12 times a night with pain and a numb leg, and never imagined there could be hope for a return to health. Stem cell therapy with Dr. Brandt is one of the smartest moves I’ve ever made.”

-Sunny from Seattle; Google Review

Great Experience and Caring Staff
“Professional at front desk. All are professional. Alison [Patient Coordinator] is very good at her job. I really appreciate the ‘down home’ attitude from all who work here. Thank you Dr. Brandt for your great expertise and caring.”

-Janet from Colorado, Patient Follow-Up

Finally Pain Free
“Dr. Brandt is one of the most caring doctors. He takes the time to listen to his patients and thoroughly explain his recommendations. He is extremely gifted in performing stem cell procedures. My back remains 95% pain free since my lumbar disc treatment 18 months ago.”

Patient from Vail, Colorado; Vitals.com Review

Returning for Another Injection
“I am a 66 year-old male who has had several injuries over many years: Torn medial meniscus in the right knee; fractured vertebra in low back; torn muscles in right shoulder; severe whiplash injuries causing significant problems in my neck. I’ve had two series of injections at ThriveMD over the past year. I had my right knee done twice; my neck done once; my right shoulder done once and my low back done once. Each of these areas have exhibited significant improvement. There is a vast improvement in pain levels in all areas. I will be returning to ThriveMD for a left knee injection next summer.

I previously worked as an Orthopedic Physician’s Assistant, and as such am very familiar with injuries (both chronic and emergent) and I have recommended Dr. Brandt to many people who are interested in improving their lives.”

-Michael from Florida; Google Review

Avoiding Spinal Fusion
“ThriveMD, This is a follow-up note as I have just undergone a bone marrow and platelet rich plasma ‘booster’ injection into my lower lumbar compromised discs. It’s been (6) weeks since the original comprehensive procedure and I am extremely grateful for the obvious progress up to this point already. I feel absolutely blessed that Dr. Brandt has been able to show me how powerful Adult Stem Cells are in the regeneration process for a host of acute & chronic conditions. My deepest gratitude for allowing me to experience the future of medicine. You can’t put a price tag on health and wellness; however the ThriveMD program is very reasonable, cost-effective, and truly game-changing. In my particular case, the timing of this new type of very effective medicine can only be explained as divine synchronicity in avoiding a spinal fusion. From the bottom of my heart – THANK YOU! Happy Holidays & A Very Prosperous 2016. Love & Light to you and your very professional staff. Warmest Regards, Jeremy”

-Jeremy from Castle Rock, Colorado; Facebook Testimonial

Back on the Bike
“I blew out my back racing in early July and decided to wait until fall to have a stem cell / bone marrow treatment done when I blew out my shoulder in another race. I had a partially torn rotator cuff, bicep, and labrum along with an impact fracture. I elected to try the stem cell / bone marrow treatment instead of rotator cuff surgery. I had both procedures done in early December and started physical therapy three weeks later. I was back on the bike in late January and kept slowly pushing it from there. As of June I am riding without pain in my back or shoulder. I have good power and full motion in my shoulder. Based on the results thus far, I consider the procedure 100% successful.”

Ron from Vail, Colorado; Vitals.com Review

20 Years of Back Pain Ended
“Dr. Brandt provided excellent care and a thorough diagnosis of my problem. My stem cell procedure was smooth and without complications. My degenerative disk pain is 90% improved. I have suffered for 20 years with back pain and finally am able to experience pain free activities. I can’t say enough good things about my experience at ThriveMD. They have a top notch staff and the office was state-of-the-art.”

-Vitals.com Review

Trust in Dr. Brandt
“Dr. Brandt is amazingly knowledgeable on the body mechanics in general and the ability for a stem cell procedure to help or not. I trust and respect his knowledge and capability.”

Jeff from Denver, Colorado; Patient Testimonial

Lower Back as Good as New for the Ski Season in Vail, CO
“Dr. Brandt is a pioneer in this promising field and we are fortunate to have him in the Vail Valley. I believe the discs in my lower back will be as good as new by the 2015 ski season based on my three month recovery since having two rounds of stem cell injections in June.”

Steve from Denver, Colorado; Email Testimonial

Highly Recommended before Knee Replacement
“Dr. Brandt was thorough in evaluating my possibility of improvement through stem cell therapy. He wanted to see my xrays & MRIs before making that determination, along with face-to-face consultation before proceeding with therapy. Approximately 4 months after my procedure, I see continued improvement in the injured knee & look forward to even more. I highly recommend this as a consideration before knee replacement.”

-Raymond, Google Review

Stem Cell Therapy for a Partial ACL Tear
“Dr. Brandt and his entire staff are amazing! Early in the ski season I had a partial tear in my ACL and thought I would be out until the next year for sure. However after consulting with Thrive MD they informed me that I was a good candidate for stem cell therapy. I went through the procedure and went from barely being able to walk with crutches to walking comfortably and normally within three weeks! I was back at work quickly and just got back on the mountain recently. My knee feels very solid and I have ZERO issues with it. Thank you Thrive MD for saving my ski season!”

-Brad from Vail Valley; Google, Facebook, & Vitals.com Review

Dr. Brandt Is an Exceptional Doctor
“I chose Dr. Brandt after searching for a stem cell clinic for over a year. I was very pleased with everyone in the office. They answered all of my questions and were always quick to do so. Dr. Brandt is an exceptional doctor. I had stem cell treatments in both shoulders. Now 3 months later, my right shoulder is pain free and the left, which has bone spurs and tears is progressing in a positive direction, just more slowly. Dr. Brandt is very approachable and helpful. I would recommend him to anyone looking for a very thorough stem cell treatment.”

-Vitals.com Review

Stem Cell Injections Helped Me Immediately
“Due to the fact that I was making the trip from Canada, I did quite a bit of research before choosing ThriveMD including having a conversation with someone who used the clinic several years ago. I found the stem cell injections to have an immediate impact on reducing pain and inflammation. The condition of my knee is pretty severe and now, a year later, I still have significantly improved mobility and less pain and inflammation. Dr. Brandt really knows his stuff. He and all the staff there are professional and efficient. They make you feel at ease and unstressed. The clinic is spotless and easy to access. The procedure is a little uncomfortable for a few days but relatively painless. If you are having second thoughts about going there, I strongly recommend that you just go. You won’t regret it.”

-Doug, Google Review

Stem Cell Injections from a Great Doctor
“Great doctor! Great staff! I shopped around and was happy with the price. I had plasma injections done in my knees. It was an easy procedure and my knees healed up great! I think it’s really important to take it easy after the procedure so you can heal faster. My recovery took a while because I was overly active.”

-Cystal, Google Review

Knees Seem 10 Years Younger
“The doctor and staff were very supportive and answered all questions. The procedures (Stem Cell) went well and my knees seem 10 year younger after 5 months of healing. I am skiing bumps :-)”

-Jon, Google Review

ThriveMD Is the Perfect Match for a Stem Cell Clinic
“I chose Dr. Brandt after searching for a stem cell clinic for over a year. I was very pleased with everyone in the office. They answered all of my questions and were always quick to do so. Dr. Brandt is an exceptional doctor. I had stem cell treatments in both shoulders. Now 3 months later, my right shoulder is pain free and the left, which has bone spurs and tears is progressing in a positive direction, just more slowly. Dr. Brandt is very approachable and helpful. I would recommend him to anyone looking for a very thorough stem cell treatment.”

-Cathy, Google Review

I Can Walk without Pain Again!
“I have no words on how amazing EVERYONE is and how I am feeling now after five months of last procedure. Is it worth the cost? If you are like me , who can not sit still/very active in 40’s with bumbling grand babies that always want to be held and bounced, the cost was and always will be the BEST investment I’ve ever made!!! My health! I can not thank Thrive MD enough for letting me walk again without pain!”

-Tiffany, Google Review

Avoided Two Knee Surgeries, Snowboarded 70 Days
“ThriveMD have done stem cells for both of my knees. I’ve had snowboarding injuries and was recommended two major ortho surgeries for the knees – sucky option, so I looked for alternatives. Dr. Brandt’s stem cells have worked like a charm. I also started to take a better care of the knees myself. Now I almost never have pain, I’m avoiding the knee surgeries, and I’m probably in the best shape I’ve ever been in. Even the recovery after stem cell procedures was just pleasant – I swam, did yoga, cycled. No need for a full break in activity, all I avoided for a month was impact and torque. This last snow season I had about 70 days of snowboarding. Super duper quadruple happy with the results. One other time I also had post-surgery IV administered at Thrive – that was the first time that week I felt alive again. Stellar clinic. I hope their procedures become commonplace for more people.”

-Branko from Mammoth Lakes, California; Facebook Review

My Knees Feel Like I’m 30 Again
“Thank you so much for checking in, I will keep you updated as I move forward. I need to tell you that my knees are so amazingly awesome, I have zero knee pain, I will forever be grateful for you helping me with the stem cell procedure and if needed I may come back for a booster down the road, but for now, they actually do feel like I’m 30 again.”

-Patient, Email Follow-Up

Greater Range of Motion for Both Knees and Shoulders
“I am very pleased with the results of my stem cell injections. I had the procedure done about 8 months ago and each month I have seen improvement. I am able to walk up and down hills easier and have greater range and motion of both my knees and shoulders. There was no pain or swelling after the procedure. I am hoping that the improvement continues.”

-Lydia from Denver Metro Area; Google Review

Far Exceeded My Expectations
“The stem cell treatment I had for my shoulder from Dr Brandt at Thrive far exceeded my expectations. Before the treatment I could barely do a single press-up and swimming even breaststroke was difficult. Now press ups are no problem and neither is swimming overarm. The increase in range of motion and decrease of discomfort in the shoulder started within about 2 weeks of the treatment and improved steadily over the next 6 months. Well worth it –and they are very nice people too!”

-Ian, Google Review

Knee Pain Gone in Two Weeks
“I was having terrible knee pain all the time, was difficult to just walk and use the stairs. Was referred to Dr. Brandt and Thrive MD by a friend. I had my consultation and found out that I would be a great candidate for stem cell therapy. I had by procedure on Nov 22, 2017 and within two weeks my pain which on a scale of 1-10, was 7-8 all the time went to 0-1. I’m now 3 months post procedure and I have 0 knee pain. I would highly recommend Dr. Brandt and his team. Very, Very Satisfied.”

-Kevin, Google Review

Able to Walk Long Distances Again
“In February of 2017, I went to Thrive MD to get stem cells injected in my knees. I have had pain for 5-7 years that did not allow me to walk more than 5 blocks without stopping and stretching. I have had many Steroid injections, years of Physical Therapy, braces, orthotics for my shoes, nothing worked. I was told I needed a total knee replacement and at 52, I didn’t want that. Dr. Brandt was a recommend to me by another Doctor that had the procedure. The first 2 weeks were not great, but then my knees really started to feel better going up and down stairs. Every month they got better and better, I am able to walk long distances now and am back to all normal activities. I highly recommend Dr. Brandt and Thrive MD.”

-Vitals.com Review

Back to Regular Activity
“When I was told by an orthopedic doctor I needed double knee replacement I chose stem cell therapy instead. Stem cell therapy has helped me get through my days without the pain I was experiencing and enjoy the activities I was unable to because of the pain.”

-Linda, Google Review

80% Reduction in Knee Pain
“After only 3 weeks, I have an 80% reduction in my knee pain. I will be climbing Mt. Kilimanjaro in 4 months, and I will be ready.”

Susan from Highlands Ranch, CO; Patient Follow-Up

No More Sleep Lost Due to Knee Pain
“Dr. Brandt and his staff were all very professional. The procedure went very well, no problems at all. It has been one year since I’ve had both knees done with stem cells. Before I had almost constant pain & discomfort. I could not walk more than about a block before. Now I can make a milk on a track. I still have some aches, but none of the pain where I can not sleep at night. I will be 75 years old next month. I am not saying I have teenage knees again, but they are great for my age. I can even play a little racquetball once in a while. Dr. Brandt, his nurse, and receptionist all treated me with respect and put me at ease.”

Herman from Wisconsin; Patient Follow-Up

Quality Care and Professionalism
“Scott – Just a quick note about the procedure(s) on my knees this week. I wanted to thank you for your care and professionalism. It was indeed a ‘pain free’ event. I’m not sure how you do it, but it is most appreciated. Keeping my fingers crossed that things will work.”

Bob from Eagle County, CO; Patient Follow-Up

Much More Skiing, No Icing
“I just wanted to give an update regarding the stem cell procedure performed by Dr. Brandt at Thrive about 3 years ago. My range of motion continues to improve–remarkable at 64.I skied 150k in 5 days last week and never iced my knee once. I can’t remember skiing that many feet w/out having to ice in the last 20 years. The knee treated has been without an acl since I was 18 and is pretty severely arthritic, but I am getting better performance now than I have in recent memory. Thank you, Dr. Brandt!!”

John from Boulder, CO; Google Review

Dr. Brandt Is The Best And Would Never Want to See Anyone Else
“Dr. Brandt is the best! I’ve been seeing him altogether for around 15 years now for corticosteroid injections for pain and would never want to see anyone else. He is very skilled with the needle and getting the injections done in exactly the right places. In addition, I’ve found Dr. Brandt to be a very concerned and caring individual; he’s a great listener who clearly gives a lot of thought to what the best approach is going to be in dealing with the situation the patient describes. I’ve found that he always takes as much time as necessary to assess the situation; dealing with Dr. Brandt is such an entirely different experience than virtually every other meeting I’ve had with various surgeons and other M.D.’s. His staff is also very friendly, helpful and kind–as I said, he’s the best…and well worth the drive to Edwards!”

-Sylvia Baldwin, Google Review

Stem Cell Treatment Helped Me Avoid Knee Transplant
“I’m extremely fortunate to have been referred to Dr. Brandt by a former patient! I was told by my orthopaedic surgeon I needed a knee transplant in the near future. Now I don’t - thanks to Dr. Brandt and his excellent staff. I would not hesitate if I needed treatments on any other joint.”

-Linda from West Chester, PA, Patient Follow-Up One Month Post Procedure

Stem Cells Healed Achilles where Traditional Treatments Failed
“After struggling with an Achilles injury for 1 1/2 years and trying everything to heal it – steroid, physical therapy, wearing a boot, no activity, stretching, etc – I decided to have stem cell therapy at Thrive.md. It was a short procedure and an afternoon of post op recovery, which after 6-8 weeks, resulted in a full recovery from my injury. This seemed to finally stimulate blood flow and healing to an injury I had resigned myself to having forever. I highly recommend this procedure for tendon injuries like this one.”

-Lisa from Chicago, Google Review

Looking Forward to Returning to Competitive Soccer
“I am a pain management physician myself. I am 52, and physically very active. I still play soccer competitively. Six months ago I suffered a hip injury with a labrum tear. Due to the pre-existing wear and tear, the only conventional treatment which was offered to me was total hip replacement. I wanted to remain physically active and continue to play sports, so I decided that this is not the best option for me.

I choose instead to try stem-cell therapy. Ten days ago I had my procedure done by Dr. Brandt, and since then I have nothing but positive things to say about him and his practice. Everyone in his office was extremely welcoming and put me at ease and comfort about my procedure. The procedure went very smooth. And I did not have ANY post procedure pain or discomfort. I had no need for any pain medication. I was back to work seeing patients on the 2nd day after the procedure. My hip already feels noticeably better.

I have the second procedure scheduled in four weeks, and I am confident that in another 3-4 weeks I’ll be back playing soccer again. Thank you, Dr. Brandt and team for taking such excellent care of me.”

-Zvezdomir from Maryland, Google Review

No More Need to Ice the Knees
“I was spending hours each day icing my knees and using ibuprofen every 8 hours. I do not have to do that now. My Achilles pain is almost completely gone. The procedure was very easy and the whole experience was very positive.”

Kim from Iowa, Patient Follow-Up One Month Post Procedure

Very Professional
“Very professional doctor & staff. Nice facility and very clean.”

Lary from Tucson, AZ; Patient Follow-Up One Month Post Procedure

Skied 52 Days Last Season
“One year later update – ankle is doing great. Skied 52 days in 2015-16. Hiking, biking and all are no problem. Great team of caring people who know their business.”

-Laurel from Edmond, Oklahoma; Google Review

Would Do It Again
“It has been a very good experience. Everything is very professional and very caring. So far I am happy with the results and would do it again.”

-Herman from Wisconsin, Patient Follow-Up

Results Near Miraculous
“Dr. Brandt has done stem cell injection therapy on my left Achilles, right knee and right shoulder and AC joint. In every case the procedure was relatively easy, the recovery time was very minimal and the results were near miraculous! I can do things now that I thought were beyond me forever. I am a believer!!”

-Harvey from Vail Valley, Colorado; Patient Follow-Up

Skiing Is Fun Again
“I have had both ACL’s replaced. The first 35 years ago and the second 25 years ago. Over the years I had a few other procedures including another surgery to clean up one of the knees. Nothing worked as well as the stem cell procedure that Dr. Brandt performed. With the slow deterioration of my knees it had become uncomfortable to ski. After having the stem cell procedure last spring, this season skiing is fun again. I never thought I would ski the bumps like that again!”

-Steve from Aspen, Google Review

Delighted with the Result
“I am delighted with the result Dr Brandt achieved, the increase in range of motion and decrease in discomfort in my shoulder were way beyond what I had hoped for. So glad that a series of coincidences led me to his door.”

-Ian from Bermuda, Vitals.com Review

Back to Enjoying the Mountain
“My husband thought he would miss out on the entire ski season after partially tearing his ACL in November. After having stem cell treatment 6 weeks ago by Dr. Brandt, he is enjoying the mountain with me and we couldn’t be happier!”

-Sue, Facebook Testimonial

Returned for Shoulder Treatment after Successful Knee & Achilles Tendon Procedure
“Great experience. The Thrive team with Dr. Brandt is superb! Explanation of procedures is complete and understandable. The process is quick and very painless. The results are amazing! [Previous stem cell procedure of] Right knee, left Achilles tendon and [now] right shoulder showing miraculous improvement! Can run, jump, throw, ski and golf. Life is good!” *

-Harvey from Vail Valley, Colorado; 1-Month Patient Follow-Up Appointment

Attentive, Concerned & Caring
“Attentive, concerned & caring – doctor & staff.”

-Judith from Littleton, Colorado; 1-Month Patient Follow-Up Appointment

Avoided Knee Replacement and Back to Being Active
“I had stem cell therapy with Dr. Brandt one year ago and I am thrilled! I avoided knee replacement! I am able to do everything I want to do. I walk, swim and bike and have no discomfort. I highly recommend this therapy!” *

Posted on Facebook reviews

-Jan from Missouri, Facebook

77 Years Young
“Had stem cell procedure for hip instead of replacement … have not taken a pain pill in the last two years. Wonderful treatment, staff and follow-up.”

Cynthia from Boynton Beach, Florida; Vitals.com Review

Real and Amazing
“This is not voodoo. This is real and amazing.”

-Bruce from Evergreen, Colorado; Patient Follow-Up

Back to Workout and Running
“I have had several stem cell injections and my knee pain has improved continuously over 18 months. I can now workout almost pain-free and even run once more! I would consider this therapy again for another joint. Dr. Brandt and his staff have been wonderful and my experience at Thrive has been pleasing.”

-Richard from Denver, Colorado; Patient Follow-Up

Stem Cells Gave Hope
“I would like to thank you and your staff for providing state of the art stem cell therapy. I realize Stem cell research is still in its infancy; however evidence is mounting that it is working. My husband is 4 years into an undiagnosed neurological problem that has mimicked MS, Parkinson’s, ALS and several other horrible diseases. Instead of waiting for him to get worse, we chose to visit your clinic. You not only listened to our plight but made me feel comfortable with your abilities to perform the procedure; a procedure that many hospitals are doing in trials currently! My husband made it through the procedure with very little discomfort and didn’t even need pain medication after. Three months after we are noticing what appears to be steady and substantial improvement in his strength, balance and attitude. We are forever grateful that we did not have to travel to a foreign country to receive this procedure. I would recommend you and your staff to anyone considering this procedure. You gave us more than stem cells you gave us hope!”

-Judy from Olathe, Kansas; Patient Follow-Up

Avoided Shoulder Replacement
“I have been completely satisfied with stem cell outcome – the left shoulder has 95% range of motion and the pain is significantly improved. My right thumb and wrist remain slightly problematic but are much improved. *AVOIDED SHOULDER REPLACEMENT*”

-Jean from Vail Valley, Colorado; Patient Follow-Up

Great Alternative to Surgery
“The injections in soft tissue of left replaced knee have made a HUGE difference. The right knee is continuing to get better noticeably each week. Everything I do is getting easier because I’m not in constant pain. I never want another knee replacement. My experience with Thrive has been enjoyable.”

-Brenda from Granby, Colorado; Patient Follow-Up

Never Another Knee Replacement
“Best medical decision I ever made! The stem cell procedure is quick, easy and has no recovery down time! Great alternative to surgery if that is an option. Dr. Brandt and his team are first class. I highly recommend them as your first choice!”

-Harvey from Vail Valley, Colorado; Patient Follow-Up

Preventing Rotator Cuff Surgery
“ThriveMD healed my torn Rotator Cuff preventing me from shoulder surgery. I was golfing 6 weeks after treatment. Dr Brandt is the best.”

-Debbie from Denver, Colorado; Facebook Testimonial

61 Years Old and Back to Daily Gym and Colorado Golf
“I am 61 yrs old. (Almost bone on bone both knees/had this stem-cell procedure done on both knees) knees feel like when I was back in my twenties (pain free/and no more arthritis pain / walking UP stairs pain free). I tell everyone that has problems with their joints about this procedure and Highly recommend having this simple procedure done for PAIN-FREE-the-rest-of-your-life joints . Because I had this procedure done: I am back at the gym going 100% two hours a day on the elliptical machine and was able to lose in three months sixty pounds. My job is very physical at times… but now I physically feel I can do my job another ten years easily and I can play golf and run again pain free. It has been a long time since I could do that. I cannot thank Dr. Brandt enough.”

-Tom from Arvada, Colorado; Facebook Testimonial

Successful Alternative to Total Knee Replacement
“I had knee issues for many years. My doctor told me it needed to be replaced several years ago, and the damage was too extreme to do only a partial knee replacement. I lived with the pain and when I was at the point of replacing the knee I found out about ThriveMD. I did the procedure and for over a year have been able to do things I hadn’t been able to do in many many years. I am still amazed at how effective the treatment is.”

-Sandy from Colorado Springs, Colorado; Google Review

Feeling Much Better One Month Post-Procedure
“My knee feels so much better after stem cell therapy. I can do just about everything I want to do after only one month. I hope to be able to hike soon. Thanks Dr. Brandt!”

-Jan from Poplar Buff, Missouri; Email Testimonial

Fellow Physician Avoided Total Knee Replacemen
“I am 58 years old and had been very active. My right knee had been getting progressively worse over the previous two years. An orthopedic surgeon told me that I had significant arthritis in the medial side of my knee and my best bet was a total knee replacement. He also mentioned that I might look into stem cell treatment. After a long discussion with Dr. Brandt and my own research, I decided to go ahead with his stem cell therapy regimen. The down time was minimal (especially compared to rehab after a total knee) and the results have been better than I hoped for. In the past month I have been on several long hikes with minimal pain. I forgot my walking sticks and hardly even noticed. Previously I would not dream of going for a hike without the sticks! As a fellow physician I found him thoroughly professional and well read on the subject. I had, and still, have no second thoughts about letting him stick a needle anywhere in my body (something I would not say about many physicians). His office is comfortable, very clean and I was quite pleased with his sterile technique. His office staff is welcoming and reassuring. Would not hesitate to go back for more!”

-Herb from Evergreen, Colorado; Patient Follow-Up

Both Knees Pain Free
“First of all I’m glad I did both knees. I can’t tell you how pleased I am with the results, the left knee is like brand new, and the right knee is 100% better than before and seems to getting better each week. I’ve been working out with the weights, getting stronger each week along with spinning on the bike two to three times a week. Should be good to go in time for ski season. Note both knees are pain free. I really feel the extra injections we did really turned the corner.

One suggestion: I really think taking at least 6 weeks after the procedure of taking it easy and let the stem cells do their thing will give the best results.”

-Bob from Denver, Colorado; Email Testimonial

Pain Free and Excited about ThriveMD Experience
“I just wanted to let you and Dr. Brandt know how well I am doing. I have been completely pain free for about five days. My strength in the hip is down but is coming back. I am very pleased with my results and am only sorry I won’t get to come visit you again. You are probably the happiest practice I have ever been involved with and I enjoyed my experience with all of you. Thank you.”

-Rick from Dallas, Texas; Email Testimonial

First Skiing in Three Years
“I had stem cell procedure done 6 months ago. Since that procedure I have been able to increase my activity with less pain. I recently skied for the first time in 3 years. I have noticed a decrease in pain as time has passed, constantly getting better. I also played golf without a brace on my knee which was not possible before the procedure.”

-David from Miami Beach, Florida; Email Testimonial

59 and Back to Skiing, Biking, Jogging
“I am a 59 yr-old never-die athlete. I have recently had stem cell injections via Dr. Brandt. My pain on a 10 scale prior was a 10, bone on bone, both knees, primed for replacement surgery. My pain now is a 3, I’m skiing, biking, even jogging uphill. I’m a believer.”

-Pat from Vail Valley, Colorado; Email Testimonial

Easy and Pain-Free Procedure
“I called Dr. Brandt’s office and they made everything so easy, I had a bit of anxiety as earlier in the spring I had a steroid shot at Mayo Clinic that was extremely painful. I received a call from the doctor to discuss my treatment options and his recommendations, his office staff responded to every call and email from me immediately. This office made me a priority and that was very important to me.

The procedure was so easy and pain free I did both knees and my left rotator. They did it under x-ray guidance and I could see exactly where my stem cells were going, right into the worn area of my knee cartilage and my cartilage soaked it right in. It was nice to see the doctor get excited about my body’s response.”

-Linda from Paradise Valley, Arizona; Email Testimonial

Off Pain Medication, Back to Mobility
“LOVE LETTER TO THRIVEMD

In 1964, the tips of my skis hit a snow bank and my bindings didn’t release. At the time I knew something very very bad had happened! In the olden days, otoscopic surgery hadn’t been invented, so an incision was made from the medial clear across to the lateral knee and 80% of the cartilage was removed. Skip ahead 5 decades to an arthritic, painful knee that doesn’t work well at all (And since the other knee has been taking most of the walking brunt, it isn’t in good shape, either)

I was taking pain-pills just to get out of bed and be semi-functional. I asked the orthopedic surgeon at my HMO about alternatives (including stem-cell injections) and he tossed me a metal/plastic contraption that was about as big as a toaster (or so it seemed to me) saying that was as good as I could do.

I had been researching stem cell research for several years and throughout I would have to go out of the country for treatment (thereby risking unforeseen consequences then and in the future). Through a series of synchronistic happenings, I discovered ThriveMD took stem cells from adipose tissue and mixed it with a patient’s own platelet-rich plasma (PRP). They then inject it into joints with the aid of fluoroscopy. I decided to get the procedure, and was jumping off the table and home within two hours. After 10 days, there was no discomfort from the procedure and I began reducing my pain medication. As I write this love note to my benefactors, I haven’t had to take anything for pain!

MY LIFE HAS CHANGED, MY KNEES ARE EVER SO HAPPY AND I’VE NOT HAD TO TAKE ANY PAIN PILLS SINCE THE FINAL INJECTION OF PRP!!!

THANK YOU FOR GIVING ME BACK MY PAIN-FREE MOBILITY AND THE POTENTIAL TO GROW BACK NEW CARTILAGE.”

-Jane from Denver, Colorado; Email Testimonial

Video Reviews

Stem Cell Therapy Research Articles

Stem cell therapy is a fascinating field of medicine with enormous amounts of research devoted to its advancement. Below is a group of relevant stem cell research articles and scientific publications for those who are interested in a deeper review and additional insight into ongoing studies.

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Erectile Dysfunction (ED) affects 10 percent of the population worldwide. In 1995 it was estimated that 152 million men were affected by ED. It is estimated that by 2025 352 million of population worldwide will be affected. Currently there is not available treatment that can restore or regenerate the tissues in the corpus cavernosum or arterial system tthat will cure ED a 20 percent failure rate with present therapies and high rate of drop out in patients with ED due to radical prostatectomy and post radiation. Testosterone eplacement is the only independent risk factor that might help endothelial dysfunction and consequently ED. Adipose tissue is abundant and easy to collect from a miniliposuction. The procedure consists in collecting a lipoaspirate of 60 ml. No general Anesthesia is required. It is an outpatient procedure. Adipose tissue is processed using a non animal collagenase enzyme. Stromal vascular fraction (SVF) is isolated. Blood is obtained through a venipuncture. Platelet rich-plasma (PRP) is obtained. The SVF is suspended in PRP. The mixture is injected into the corpus cavernosum using our designed protocol for injection.

Four types of patients: DM, ED due to prostatectomy and radiation, Peyronie’s disease, and ED organic cause/aging/vascular. Patients filled out the intensity score questionnaire before and after procedure. Both reported better erections in the morning, firmer, and better response to PDI5 inhibitors for which they were not responders prior to the treatment. This might be due to stem cells induced regeneration of the cavernous nerve and endothelial cells enhancing the nitric oxide production hence improved response to PDI-5 inhibitors.

Abandoning Microfracture of the Knee: Has the Time Come?

 PUBLISHED on The Journal of Arthroscopic and Related Surgery, 2015    AUTHORS Jack M. Bert, M.D.

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Marrow stimulation has been performed for more than 45 years beginning with the simple drilling of bony surfaces, burring or “abrading” the sclerotic lesion, and more recently using awls to penetrate eburnated bone to promote blood flow to the bony surface. Multiple authors have promoted these procedures as “helpful,” but others have confirmed only short-term relief with destruction of the subchondral surface. Unfortunately, proponents do not compare their marrow stimulation results to a control group that had debridement alone. A recent study confirmed that microfracture (MF) is equivalent to debridement and does not affect the subchondral bone, which therefore does not reduce the success rates of future surgery subsequent to MF. This brief review summarizes some of the factual data showing that marrow stimulation may not offer any improvement over debridement alone and that, in fact, MF results in significant destruction to the subchondral bone.

Regenerative Repair of Damaged Meniscus with Autologous Adipose Tissue-Derived Stem Cells

 PUBLISHED on BioMed Research International by Jaewoo Pak et al., 2014.    AUTHORS Jaewoo Pak, Jung Hun Lee and Sang Hee Lee.

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Mesenchymal stem cells (MSCs) are defined as pluripotent cells found in numerous human tissues, including bone marrow and adipose tissue. Such MSCs, isolated from bone marrow and adipose tissue, have been shown to differentiate into bone and cartilage, along with other types of tissues. Therefore, MSCs represent a promising new therapy in regenerative medicine. The initial treatment of meniscus tear of the knee is managed conservatively with nonsteroidal anti-inflammatory drugs and physical therapy. When such conservative treatment fails, an arthroscopic resection of the meniscus is necessary. However, the major drawback of the meniscectomy is an early onset of osteoarthritis. Therefore, an effective and noninvasive treatment for patients with continuous knee pain due to damaged meniscus has been sought. Here, we present a review, highlighting the possible regenerative mechanisms of damaged meniscus with MSCs (especially adipose tissue-derived stem cells (ASCs)), along with a case of successful repair of torn meniscus with significant reduction of knee pain by percutaneous injection of autologous ASCs into an adult human knee.

Intra-Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: a Proof-of-Concept Clinical Trial

 PUBLISHED on Wiley Online Library by AlphaMed Press, 2014.    AUTHORS Jo CH, Lee YG, Shin WH, Kim H, Chai JW, Jeong EC, Kim JE, Shim H, Shin JS, Shin IS, Ra JC, Oh S, Yoon KS. 

 KEYWORDS Adipose-tissue derived mesenchymal stem cells; Cartilage regeneration; Intra-articular injection; Osteoarthritis.

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Mesenchymal stem cells (MSCs) are known to have a potential for articular cartilage regeneration. However, most studies focused on focal cartilage defect through surgical implantation. For the treatment of generalized cartilage loss in osteoarthritis, an alternative delivery strategy would be more appropriate. The purpose of this study was to assess the safety and efficacy of intra-articular injection of autologous adipose tissue derived MSCs (AD-MSCs) for knee osteoarthritis. We enrolled 18 patients with osteoarthritis of the knee and injected AD MSCs into the knee. The phase I study consists of three dose-escalation cohorts; the low-dose (1.0 × 10(7) cells), mid-dose (5.0 × 10(7)), and high-dose (1.0 × 10(8)) group with three patients each. The phase II included nine patients receiving the high-dose. The primary outcomes were the safety and the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) at 6 months. Secondary outcomes included clinical, radiological, arthroscopic, and histological evaluations. There was no treatment-related adverse event. The WOMAC score improved at 6 months after injection in the high-dose group. The size of cartilage defect decreased while the volume of cartilage increased in the medial femoral and tibial condyles of the high-dose group. Arthroscopy showed that the size of cartilage defect decreased in the medial femoral and medial tibial condyles of the high-dose group. Histology demonstrated thick, hyaline-like cartilage regeneration. These results showed that intra-articular injection of 1.0 × 10(8) AD MSCs into the osteoarthritic knee improved function and pain of the knee joint without causing adverse events, and reduced cartilage defects by regeneration of hyaline-like articular cartilage.

Stem Cell Therapy Following Meniscus Knee Surgery May Reduce Pain, Restore Meniscus

 PUBLISHED on Digital Journal by The American Academy of Orthopaedic Surgeons (AAOS), 2014.

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Key Study Findings

  • There was no abnormal (ectopic) tissue formation or “clinically important” safety issues identified.
  • There was “significantly increased meniscal volume,” determined by an MRI in 24 percent of the patients in the low-dose injection group (A) and six percent of the high-dose injection group (B) at one year. There was no statistical increase in meniscal volume at two years.
  • No patients in the control group (non-MSC group) met the 15 percent threshold for increased meniscal volume.
  • Patients with osteoarthritis experienced a reduction in pain in the stem cell treatment groups; there was no reduction in pain in the control (non-MSC group).

Adult Human Mesenchymal Stem Cells Delivered via Intra-Articular Injection to the Knee Following Partial Medial Meniscectomy

 PUBLISHED in The Journal of Bone & Joint Surgery Inc., 2014.    AUTHORS ; ; ; ; ; .

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Background: There are limited treatment options for tissue restoration and the prevention of degenerative changes in the knee. Stem cells have been a focus of intense preclinical research into tissue regeneration but limited clinical investigation. In a randomized, double-blind, controlled study, the safety of the intra-articular injection of human mesenchymal stem cells into the knee, the ability of mesenchymal stem cells to promote meniscus regeneration following partial meniscectomy, and the effects of mesenchymal stem cells on osteoarthritic changes in the knee were investigated.

Methods: A total of fifty-five patients at seven institutions underwent a partial medial meniscectomy. A single superolateral knee injection was given within seven to ten days after the meniscectomy. Patients were randomized to one of three treatment groups: Group A, in which patients received an injection of 50 × 106 allogeneic mesenchymal stem cells; Group B, 150 × 106 allogeneic mesenchymal stem cells; and the control group, a sodium hyaluronate (hyaluronic acid/hyaluronan) vehicle control. Patients were followed to evaluate safety, meniscus regeneration, the overall condition of the knee joint, and clinical outcomes at intervals through two years. Evaluations included sequential magnetic resonance imaging (MRI).

Results: No ectopic tissue formation or clinically important safety issues were identified. There was significantly increased meniscal volume (defined a priori as a 15% threshold) determined by quantitative MRI in 24% of patients in Group A and 6% in Group B at twelve months post meniscectomy (p = 0.022). No patients in the control group met the 15% threshold for increased meniscal volume. Patients with osteoarthritic changes who received mesenchymal stem cells experienced a significant reduction in pain compared with those who received the control, on the basis of visual analog scale assessments.

Conclusions: There was evidence of meniscus regeneration and improvement in knee pain following treatment with allogeneic human mesenchymal stem cells. These results support the study of human mesenchymal stem cells for the apparent knee-tissue regeneration and protective effects.

You May Not Be Better Off After Knee Surgery

 PUBLISHED on CNN.com, 2013.    AUTHORS 

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Patients who underwent simulated knee surgery fared just as well as those who got the real deal, according to a new study that’s raising eyebrows about the most common orthopedic procedure performed in the United States.

Arthroscopic Partial Meniscectomy versus Sham Surgery for a Degenerative Meniscal Tear

 PUBLISHED in The New England Journal of Medicine by the Finnish Degenerative Meniscal Lesion Study (FIDELITY) Group, 2013.    AUTHORS Raine Sihvonen, M.D., Mika Paavola, M.D., Ph.D., Antti Malmivaara, M.D., Ph.D., Ari Itälä, M.D., Ph.D., Antti Joukainen, M.D., Ph.D., Heikki Nurmi, M.D., Juha Kalske, M.D., and Teppo L.N. Järvinen, M.D., Ph.D.

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BACKGROUND: Arthroscopic partial meniscectomy is one of the most common orthopedic procedures, yet rigorous evidence of its efficacy is lacking.

METHODS: We conducted a multicenter, randomized, double-blind, sham-controlled trial in 146 patients 35 to 65 years of age who had knee symptoms consistent with a degenerative medial meniscus tear and no knee osteoarthritis. Patients were randomly assigned to arthroscopic partial meniscectomy or sham surgery. The primary outcomes were changes in the Lysholm and Western Ontario Meniscal Evaluation Tool (WOMET) scores (each ranging from 0 to 100, with lower scores indicating more severe symptoms) and in knee pain after exercise (rated on a scale from 0 to 10, with 0 denoting no pain) at 12 months after the procedure.

RESULTS: In the intention-to-treat analysis, there were no significant between-group differences in the change from baseline to 12 months in any primary outcome. The mean changes (improvements) in the primary outcome measures were as follows: Lysholm score, 21.7 points in the partial-meniscectomy group as compared with 23.3 points in the sham-surgery group (between-group difference, −1.6 points; 95% confidence interval [CI], −7.2 to 4.0); WOMET score, 24.6 and 27.1 points, respectively (between-group difference, −2.5 points; 95% CI, −9.2 to 4.1); and score for knee pain after exercise, 3.1 and 3.3 points, respectively (between-group difference, −0.1; 95% CI, −0.9 to 0.7). There were no significant differences between groups in the number of patients who required subsequent knee surgery (two in the partial-meniscectomy group and five in the sham-surgery group) or serious adverse events (one and zero, respectively).

CONCLUSIONS: In this trial involving patients without knee osteoarthritis but with symptoms of a degenerative medial meniscus tear, the outcomes after arthroscopic partial meniscectomy were no better than those after a sham surgical procedure. (Funded by the Sigrid Juselius Foundation and others; ClinicalTrials.gov number, NCT00549172.)

Treatment of Knee Osteoarthritis with Autologous Mesenchymal Stem Cells: a Pilot Study

 PUBLISHED in The Transplantation Journal, 2013.    AUTHORS Orozco, Lluis; Munar, Anna; Soler, Robert; Alberca, Mercedes; Soler, Francesc; Huguet, Marina; Sentís, Joan; Sánchez, Ana; García-Sancho, Javier

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BACKGROUND: Osteoarthritis is the most prevalent joint disease and a frequent cause of joint pain, functional loss, and disability. Osteoarthritis often becomes chronic, and conventional treatments have demonstrated only modest clinical benefits without lesion reversal. Cell-based therapies have shown encouraging results in both animal studies and a few human case reports. We designed a pilot study to assess the feasibility and safety of osteoarthritis treatment with mesenchymal stromal cells (MSCs) in humans and to obtain early efficacy information for this treatment.

METHODS: Twelve patients with chronic knee pain unresponsive to conservative treatments and radiologic evidence of osteoarthritis were treated with autologous expanded bone marrow MSCs by intra-articular injection (40×10 cells). Clinical outcomes were followed for 1 year and included evaluations of pain, disability, and quality of life. Articular cartilage quality was assessed by quantitative magnetic resonance imaging T2 mapping.

RESULTS: Feasibility and safety were confirmed, and strong indications of clinical efficacy were identified. Patients exhibited rapid and progressive improvement of functional indices that approached 65% to 78% by 1 year. This outcome compares favorably with the results of conventional treatments. Additionally, quantification of cartilage quality by T2 relaxation measurements demonstrated a highly significant decrease of poor cartilage areas (on average, 27%), with improvement of cartilage quality in 11 of the 12 patients.

CONCLUSIONS: MSC therapy may be a valid alternative treatment for chronic knee osteoarthritis. The intervention is simple, does not require hospitalization or surgery, provides pain relief, and significantly improves cartilage quality.

Millennium Medical Technologies – Statement of Position towards FDA’s Stance on Stem Cell Therapy

 PUBLISHED on millenniummedicaltechnologies.com, 2013.    AUTHORS David Angeloni

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Millennium Medical Technologies is committed to further advance our core values related to the use of Adipose Derived Cells and Platelet Rich Plasma around our evidence based processes. We feel these procedures are paramount in contributing to better outcomes. It is our opinion that our component based system of FDA registered or compliant products allow a physician to practice medicine, within their own scope of expertise, using ADC’s and PRP without “minimal manipulation” and “homologous use” concerns as you are complying with cGTP. Certainly the physician shouldn’t advertise “treatment claims” with any autologous stem cells harvested/isolated in such a manner but we support and believe a physician may legally use them as a tool in their practice.

No Such Thing as Stem Cells in a Bottle

 PUBLISHED in Philippine Daily Inquirer, 2013.    AUTHORS Cheche V. Moral

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Philippines – The Department of Health and some medical organizations are calling for a clampdown on hospitals, clinics and centers offering stem cell treatments. But instead of being discouraged, one of stem cell therapy’s vocal advocates and practitioners in the country said she welcomes the move.

FDA Regulations of Stem Cell Therapy

 PUBLISHED on fda.gov, 2014.

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TITLE 21–FOOD AND DRUGS

CHAPTER I–FOOD AND DRUG ADMINISTRATION

DEPARTMENT OF HEALTH AND HUMAN SERVICES

SUBCHAPTER L–REGULATIONS UNDER CERTAIN OTHER ACTS ADMINISTERED BY THE FOOD AND DRUG ADMINISTRATION

PART 1271–HUMAN CELLS, TISSUES, AND CELLULAR AND TISSUE-BASED PRODUCTS

Adipose-Derived Stem Cells for Regenerative Medicine

 PUBLISHED in Circulation Research by American Heart Association, 2007.    AUTHORS Jeffrey M. Gimble, Adam J. Katz, Bruce A. Bunnell

 KEYWORDS adipose tissue, adult stem cells, bone marrow stromal cell, differentiation, tissue engineering

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The emerging field of regenerative medicine will require a reliable source of stem cells in addition to biomaterial scaffolds and cytokine growth factors. Adipose tissue represents an abundant and accessible source of adult stem cells with the ability to differentiate along multiple lineage pathways. The isolation, characterization, and preclinical and clinical application of adipose-derived stem cells (ASCs) are reviewed in this article.

Adipose-Derived Stem Cells: Characterization and Current Application in Orthopaedic Tissue Repair

 PUBLISHED in Experimental Biology and Medicine, 2008.    AUTHORS Hazel Tapp, Edward N. Hanley Jr., Joshua C. Patt, Helen E. Gruber

 KEYWORDS adipose-derived stem cells, orthopaedic tissue regeneration, cell-surface markers, differentiation

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ABSTRACT

Orthopaedic tissues, such as bone, cartilage, intervertebral disc and tendon, contain cells that are difficult to culture and stimulate in vitro for repair of damaged tissue. Stem cells have the ability to self-renew and differentiate into many tissue types. Recent progress in stem cell research has led to an enthusiastic effort to utilize stem cells for orthopaedic tissue regeneration. Due to ease of harvest and abundance, adipose-derived mesenchymal cells (ASC) are an attractive, readily available adult stem cell that has become increasingly popular for use in many stem cell applications. Recent progress has been made in characterizing ASC and looking mechanistically at gene expression and cellular pathways involved in differentiation. This review focuses on (i) the characterization of ASC through expression of appropriate surface markers; (ii) modulation of in vitro differentiation of ASC through different scaffolds, growth factors, and media; and (iii) the use of ASC in orthopaedic tissue repair. Strategies for repair involve the use of differentiated or undifferentiated, fresh or passaged ASC, in conjunction with appropriate choice of media, growth factors and scaffolds. Recent in vivo studies utilizing ASC are discussed giving results on defect repair and potential for clinical orthopaedic tissue regeneration.

Adipose-Derived Stem Cells: Characterization and Current Application in Orthopaedic Tissue Repair

 PUBLISHED in Experimental Biology and Medicine, 2008.    AUTHORS Hazel Tapp, Edward N. Hanley Jr., Joshua C. Patt, Helen E. Gruber

 KEYWORDS adipose-derived stem cells, orthopaedic tissue regeneration, cell-surface markers, differentiation

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ABSTRACT

Orthopaedic tissues, such as bone, cartilage, intervertebral disc and tendon, contain cells that are difficult to culture and stimulate in vitro for repair of damaged tissue. Stem cells have the ability to self-renew and differentiate into many tissue types. Recent progress in stem cell research has led to an enthusiastic effort to utilize stem cells for orthopaedic tissue regeneration. Due to ease of harvest and abundance, adipose-derived mesenchymal cells (ASC) are an attractive, readily available adult stem cell that has become increasingly popular for use in many stem cell applications. Recent progress has been made in characterizing ASC and looking mechanistically at gene expression and cellular pathways involved in differentiation. This review focuses on (i) the characterization of ASC through expression of appropriate surface markers; (ii) modulation of in vitro differentiation of ASC through different scaffolds, growth factors, and media; and (iii) the use of ASC in orthopaedic tissue repair. Strategies for repair involve the use of differentiated or undifferentiated, fresh or passaged ASC, in conjunction with appropriate choice of media, growth factors and scaffolds. Recent in vivo studies utilizing ASC are discussed giving results on defect repair and potential for clinical orthopaedic tissue regeneration.

Human Adipose Stem Cells: Current Clinical Applications

PUBLISHED in Journal of American Society of Plastic Surgeons, 2012.    AUTHORS Gir, Phanette M.D.; Oni, Georgette M.D.; Brown, Spencer A. Ph.D.; Mojallal, Ali M.D., Ph.D.; Rohrich, Rod J. M.D.

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Adipose-derived stem cells are multipotent cells that can easily be extracted from adipose tissue, are capable of expansion in vitro, and have the capacity to differentiate into multiple cell lineages, which have the potential for use in regenerative medicine. However, several issues need to be studied to determine safe human use. For example, there are questions related to isolation and purification of adipose-derived stem cells, their effect on tumor growth, and the enforcement of U.S. Food and Drug Administration regulations. Numerous studies have been published, with the interest in the potential for regenerative medicine continually growing. Several clinical trials using human adipose stem cell therapy are currently being performed around the world, and there has been a rapid evolution and expansion of their number. The purpose of this article was to review the current published basic science evidence and ongoing clinical trials involving the use of adipose-derived stem cells in plastic surgery and in regenerative medicine in general. The results of the studies and clinical trials using adipose-derived stem cells reported in this review seem to be promising not only in plastic surgery but also in a wide variety of other specialties. Nevertheless, those reported showed disparity in the way adipose-derived stem cells were used. Further basic science experimental studies with standardized protocols and larger randomized trials need to be performed to ensure safety and efficacy of adipose-derived stem cells use in accordance with U.S. Food and Drug Administration guidelines.

Human Adipose Tissue Is a Source of Multipotent Stem Cells

PUBLISHED in Molecular Biology of the Cell, 2002.    AUTHORS Patricia A. Zuk, Min Zhu, Peter Ashjian, Daniel A. De Ugarte, Jerry I. Huang, Hiroshi Mizuno, Zeni C. Alfonso, John K. Fraser, Prosper Benhaim and Marc H. Hedrick

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Much of the work conducted on adult stem cells has focused on mesenchymal stem cells (MSCs) found within the bone marrow stroma. Adipose tissue, like bone marrow, is derived from the embryonic mesenchyme and contains a stroma that is easily isolated. Preliminary studies have recently identified a putative stem cell population within the adipose stromal compartment. This cell population, termed processed lipoaspirate (PLA) cells, can be isolated from human lipoaspirates and, like MSCs, differentiate toward the osteogenic, adipogenic, myogenic, and chondrogenic lineages. To confirm whether adipose tissue contains stem cells, the PLA population and multiple clonal isolates were analyzed using several molecular and biochemical approaches. PLA cells expressed multiple CD marker antigens similar to those observed on MSCs. Mesodermal lineage induction of PLA cells and clones resulted in the expression of multiple lineage-specific genes and proteins. Furthermore, biochemical analysis also confirmed lineage-specific activity. In addition to mesodermal capacity, PLA cells and clones differentiated into putative neurogenic cells, exhibiting a neuronal-like morphology and expressing several proteins consistent with the neuronal phenotype. Finally, PLA cells exhibited unique characteristics distinct from those seen in MSCs, including differences in CD marker profile and gene expression.

President Obama and the Embryonic Backfire

PUBLISHED on Huffington Post, 2013.    AUTHORS Robin L. Smith

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It is exceptionally hard to cut through embryonic misperceptions that exist in the financial marketplace. And when you consider that biomedical and health R&D spending in the United States fell by more than $4 billion in fiscal 2011, we face an uphill battle in the years ahead in our quest to turn cells into conduits of hope and healing.

Adult Mesenchymal Stem Cells: an Innovative Therapeutic for Lung Diseases

 PUBLISHED in Discovery Medicine, 2010.    AUTHORS Tracey L. Bonfield, Arnold I. Caplan

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Adult human mesenchymal stem cells (hMSCs) are the focus of a number of clinical applications. The advantage of hMSCs is that they are immuno-modulatory and versatile due to their secreted bioactive molecules that are anti-inflammatory and regenerative. These cells have the potential to orchestrate reparative processes in diseased or injured tissues. Much of the diversity and uniqueness of hMSCs is defined by their response to the milieu of injured tissue. hMSCs are sensitive to their site-specific microenvironment, and it is anticipated that they will deliver the bioactive agents in a site-specific manner quite different from the way pharmaceutical drugs work. This review highlights current concepts of such functions with a focus on the clinical utility of hMSCs in the treatment of lung diseases.

Potential Role of Stem Cells in Management of COPD

 PUBLISHED in International Journal of COPD, 2010.    AUTHORS Tillie L Hackett, Darryl A Knight, and Don D Sin

 COPD, stem cell therapy, epithelial repair, regenerative medicine

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Chronic obstructive pulmonary disease (COPD) is a worldwide epidemic affecting over 200 million people and accounting for more than three million deaths annually. The disease is characterized by chronic inflammation of the airways and progressive destruction of lung parenchyma, a process that in most cases is initiated by cigarette smoking. Unfortunately, there are no interventions that have been unequivocally shown to prolong survival in patients with COPD. Regeneration of lung tissue by stem cells from endogenous and exogenous sources is a promising therapeutic strategy. Herein we review the current literature on the characterization of resident stem and progenitor cell niches within the lung, the contribution of mesenchymal stem cells to lung regeneration, and advances in bioengineering of lung tissue.

Stem Cell Therapy of Osteoarthritis Using Stromal Vascular Fraction Cells

 PUBLISHED in The Journal of Cell Therapy, 2013.    AUTHORS J. Michalek, Z. Kristkova, J. Skopalik, Z. Dudasova, A. Darinskas, R. Moster

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Therapy of osteoarthritis relies on non-steroid analgesics, chondroprotectives and in late stages total joint replacement is considered a standard of care. We performed a pilot study using novel stem cell therapy approach that was performed during one surgical procedure. It relies on abdominal lipoaspiration and processing of connective tissue to stromal vascular fraction (SVF) cells that typically contain relatively large amounts of mesenchymal stromal and stem cells. SVF cells are injected immediately to the target joint or to the connective tissue of the target joint.

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SUMMARY

Orthopedic surgery specialists highlight relief from arthritis through stem cells.